Format

Send to

Choose Destination
See comment in PubMed Commons below
Org Lett. 2009 May 7;11(9):1975-8. doi: 10.1021/ol900446d.

The aignopsanes, a new class of sesquiterpenes from selected chemotypes of the sponge Cacospongia mycofijiensis.

Author information

1
Department of Chemistry and Biochemistry & Institute for Marine Sciences, University of California, Santa Cruz, California 95064, USA.

Abstract

A survey of individual specimens of northern Papua New Guinea derived Cacospongia mycofijiensis has yielded novel sesquiterpenes, aignopsanoic acid A (1), methyl aignopsanoate A (2), and isoaignopsanoic acid A (3). The structures and absolute configurations of 1-3 were established using NMR data, X-ray crystallography results, and an analysis of CD properties. Two of these metabolites, 1 and 2, were moderately active against Trypanosoma brucei, the parasite responsible for sleeping sickness.

PMID:
19385671
PMCID:
PMC3762577
DOI:
10.1021/ol900446d
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments

    Supplemental Content

    Full text links

    Icon for American Chemical Society Icon for PubMed Central
    Loading ...
    Support Center