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Nano Lett. 2009 May;9(5):2077-82. doi: 10.1021/nl900513k.

A nanocube plasmonic sensor for molecular binding on membrane surfaces.

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  • 1Department of Chemistry, University of California, Berkeley, California 94720, USA.

Abstract

Detection and characterization of molecular interactions on membrane surfaces is important to biological and pharmacological research. Here, silver nanocubes interfaced with glass-supported model membranes form a label-free sensor that measures protein binding to the membrane. The technique utilizes plasmon resonance scattering of nanocubes, which are chemically coupled to the membrane. In contrast to other plasmonic sensing techniques, this method features simple, solution-based device fabrication and readout. Static and dynamic protein/membrane binding are monitored and quantified.

PMID:
19385625
PMCID:
PMC3626234
DOI:
10.1021/nl900513k
[PubMed - indexed for MEDLINE]
Free PMC Article
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