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Obstet Gynecol. 2009 May;113(5):1082-8. doi: 10.1097/AOG.0b013e3181a1f0e6.

Antenatal betamethasone administration alters stress physiology in healthy neonates.

Author information

1
Department of Obstetrics and Gynecology, University of Zuürich, Zuürich, Switzerland. schaffer@usz.chscheffer@ugz.ch

Abstract

OBJECTIVE:

To analyze hypothalamic-pituitary-adrenal axis balance in healthy newborns after antenatal betamethasone treatment for lung maturation where delivery could be prolonged until or near term.

METHODS:

In a prospective observational study, salivary cortisol and cortisone levels were measured at the fourth day of life during resting conditions and in response to a pain-induced stress event in 23 neonates with antenatal exposure to a single course of betamethasone (2x12 mg) and compared with 40 controls. The mean interval between betamethasone treatment and delivery was 60+/-23 days.

RESULTS:

On day 4 of life, neonates in the control group exhibited a significant increase in cortisol and cortisone from baseline levels after the stress induction (1.175-2.4 ng/mL for cortisol and 11.35-18.15 ng/mL for cortisone [both P<.05]), whereas, in betamethasone-exposed neonates, cortisol and cortisone stress response was not significantly different from baseline levels (1.39-1.6 ng/mL for cortisone [P=.76] and 14.8-17.1 ng/mL for cortisol [P=.69]). No influence of gestational age at betamethasone administration (P=.76) or gestational age at delivery (P=.71) on stress response patterns was observed in a multiple stepwise regression.

CONCLUSION:

A single course of antenatal betamethasone treatment induces a suppression of stress reactivity in healthy newborns.

PMID:
19384124
DOI:
10.1097/AOG.0b013e3181a1f0e6
[Indexed for MEDLINE]
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