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Chembiochem. 2009 May 4;10(7):1141-4. doi: 10.1002/cbic.200900155.

Evidence for pseudoknot formation of class I preQ1 riboswitch aptamers.

Author information

1
Institute of Organic Chemistry, Center for Molecular Biosciences CMBI, 6020 Innsbruck. Austria.

Abstract

All in a knot. The smallest riboswitch forms a pseudoknot in solution. This is demonstrated for preQ(1) class I aptamers by mutational analysis in combination with (1)H NMR-based structure probing. How pseudoknot formation mediates the mRNA response through its expression platform is now open for investigation.

PMID:
19382115
DOI:
10.1002/cbic.200900155
[Indexed for MEDLINE]

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