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Spinal Cord. 2009 Aug;47(8):582-91. doi: 10.1038/sc.2009.18. Epub 2009 Apr 21.

Outcome measures in spinal cord injury: recent assessments and recommendations for future directions.

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1
University of Alabama, Birmingham, USA.

Abstract

STUDY DESIGN:

Review by the spinal cord outcomes partnership endeavor (SCOPE), which is a broad-based international consortium of scientists and clinical researchers representing academic institutions, industry, government agencies, not-for-profit organizations and foundations.

OBJECTIVES:

Assessment of current and evolving tools for evaluating human spinal cord injury (SCI) outcomes for both clinical diagnosis and clinical research studies.

METHODS:

a framework for the appraisal of evidence of metric properties was used to examine outcome tools or tests for accuracy, sensitivity, reliability and validity for human SCI.

RESULTS:

Imaging, neurological, functional, autonomic, sexual health, bladder/bowel, pain and psychosocial tools were evaluated. Several specific tools for human SCI studies have or are being developed to allow the more accurate determination for a clinically meaningful benefit (improvement in functional outcome or quality of life) being achieved as a result of a therapeutic intervention.

CONCLUSION:

Significant progress has been made, but further validation studies are required to identify the most appropriate tools for specific targets in a human SCI study or clinical trial.

PMID:
19381157
PMCID:
PMC2722687
DOI:
10.1038/sc.2009.18
[Indexed for MEDLINE]
Free PMC Article
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