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Blood Cells Mol Dis. 2009 Jul-Aug;43(1):134-7. doi: 10.1016/j.bcmd.2009.03.006. Epub 2009 Apr 19.

Impaired IL-10 transcription and release in animal models of Gaucher disease macrophages.

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Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel.


A number of studies have shown altered cytokine levels in serum from Gaucher disease patients, including changes in levels of the anti-inflammatory cytokine, interleukin-10 (IL-10). However, the source of IL-10, or the mechanisms leading to changes in IL-10 serum levels are not known. We now show that mouse macrophages treated with an active site-directed inhibitor of glucocerebrosidase, or macrophages from a mouse model of Gaucher disease, the L444P mouse, release significantly less IL-10 than their untreated counterparts, but that TNFalpha release is unaffected. These changes are due to reduced transcription of IL-10 mRNA in macrophages. The reduction in IL-10 secretion observed in animal models of Gaucher disease macrophages may be of relevance to explain the increase in inflammation that is often observed in Gaucher disease.

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