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Biochem Biophys Res Commun. 2009 Jun 19;384(1):6-11. doi: 10.1016/j.bbrc.2009.04.051. Epub 2009 Apr 18.

Molecular mechanisms controlling E-cadherin expression in breast cancer.

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1
Department of Biochemistry and Molecular Biology, LSU Health Science Center, New Orleans, LA 70112, USA.

Abstract

Disruption of cell-cell adhesion, which is essential for the maintenance of epithelial plasticity and is mediated by a class of proteins called cadherins, is an initial event in the progression of cancer. Cadherins are Ca(2+)-dependent transmembrane proteins that are associated with actin via other cytoplasmic proteins. Disruption of cell-cell adhesion during cancer progression is an important event during cancer initiation and metastasis. E-cadherin, one of the most widely studied tumor suppressors in breast cancer, belongs to a family of calcium-dependent cell adhesion molecules. Various signaling molecules and transcription factors regulate the expression of E-cadherin. Loss of E-cadherin has been reported to induce epithelial-mesenchymal transition in several cancers. This review highlights recent advances in defining the mechanisms that regulate E-cadherin expression in breast cancer.

PMID:
19379710
PMCID:
PMC2700729
DOI:
10.1016/j.bbrc.2009.04.051
[Indexed for MEDLINE]
Free PMC Article
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