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Cell. 2009 Apr 17;137(2):203-5. doi: 10.1016/j.cell.2009.04.008.

Fallen immortals.

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  • 1Department of Chemical and Systems Biology, Stanford University, Stanford, CA 94305, USA.

Abstract

The memory of somatic cell gene expression is reset in the germline in a process that is accompanied by dramatic changes in chromatin modifications. In this issue, Katz et al. (2009) show that the histone demethylase Lsd1/Spr-5 may participate in this resetting process in the worm, thereby preventing a decline in germ cell epigenetic stability and viability over ensuing generations.

PMID:
19379684
DOI:
10.1016/j.cell.2009.04.008
[PubMed - indexed for MEDLINE]
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