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Nat Med. 2009 May;15(5):572-6. doi: 10.1038/nm.1919. Epub 2009 Apr 19.

The parametric response map is an imaging biomarker for early cancer treatment outcome.

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1
Departments of Radiology, University of Michigan, Center for Molecular Imaging, Ann Arbor, USA.

Abstract

Here we describe the parametric response map (PRM), a voxel-wise approach for image analysis and quantification of hemodynamic alterations during treatment for 44 patients with high-grade glioma. Relative cerebral blood volume (rCBV) and flow (rCBF) maps were acquired before treatment and after 1 and 3 weeks of therapy. We compared the standard approach using region-of-interest analysis for change in rCBV or rCBF to the change in perfusion parameters on the basis of PRM (PRM(rCBV) and PRM(rCBF)) for their accuracy in predicting overall survival. Neither the percentage change of rCBV or rCBF predicted survival, whereas the regional response evaluations made on the basis of PRM were highly predictive of survival. Even when accounting for baseline rCBV, which is prognostic, PRM(rCBV) proved more predictive of overall survival.

PMID:
19377487
PMCID:
PMC3307223
DOI:
10.1038/nm.1919
[Indexed for MEDLINE]
Free PMC Article
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