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Autophagy. 2009 Jul;5(5):608-15. Epub 2009 Jul 2.

epg-1 functions in autophagy-regulated processes and may encode a highly divergent Atg13 homolog in C. elegans.

Author information

1
College of Life Sciences, China Agricultural University, Beijing, China.

Abstract

Autophagy is an evolutionarily conserved intracellular catabolic system for degradation of long-lived proteins or damaged organelles. In this study, we have identified and characterized a new gene, epg-1, that plays a role in the autophagy pathway in C. elegans. Loss of function of epg-1 causes defects in various autophagy-regulated processes, including degradation of aggregate-prone proteins and optimal survival of animals during starvation. epg-1 encodes a novel protein that shows limited sequence similarity to the yeast autophagy protein Atg13. epg-1 displays a similar expression pattern to, and directly interacts with, the C. elegans Atg1 homolog UNC-51, suggesting that epg-1 encodes a divergent functional homolog of Atg13 in C. elegans.

PMID:
19377305
DOI:
10.4161/auto.5.5.8624
[Indexed for MEDLINE]

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