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Iran J Kidney Dis. 2008 Oct;2(4):234-6.

Recurrent acute kidney failure due to McArdle disease.

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Division of Nephrology, Department of Medicine, Sina Hospital, Tabriz University of Medical Sciences, Tabriz, Iran.


We present an adolescent with McArdle disease and recurrent acute kidney failure due to rhabdomyolysis. The patient was admitted with acute kidney failure for 3 times and due to a history of proximal weakness, fatigue, and muscular cramps after physical activities a glycogen-storage disease was suspected. Serum creatine phosphokinase and urine myoglobin were found to be elevated. McArdle disease was diagnosed based on pathologic examination of muscle tissue specimen. Patients presenting with rhabdomyolysis following strenuous exercise should be evaluated for McArdle disease.

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