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Appl Environ Microbiol. 2009 Jun;75(12):4194-6. doi: 10.1128/AEM.00479-09. Epub 2009 Apr 17.

Ferricrocin, a siderophore involved in intra- and transcellular iron distribution in Aspergillus fumigatus.

Author information

1
Biocenter, Medical University of Innsbruck, Austria.

Abstract

Iron is an essential metal for virtually all organisms. Iron acquisition is well characterized for various organisms, whereas intracellular iron distribution is poorly understood. In contrast to bacteria, plants, and animals, most fungi lack ferritin-mediated iron storage but possess an intracellular siderophore shown to be involved in iron storage. Here we demonstrate that deficiency in the intracellular siderophore ferricrocin causes iron starvation in conidia of Aspergillus fumigatus, demonstrating that ferricrocin is also involved in intra- and transcellular iron distribution. Thus, ferricrocin represents the first intracellular iron transporter identified in any organism.

PMID:
19376908
PMCID:
PMC2698346
DOI:
10.1128/AEM.00479-09
[Indexed for MEDLINE]
Free PMC Article

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