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Transplant Proc. 2009 Apr;41(3):898-900. doi: 10.1016/j.transproceed.2009.01.053.

Psychosocial determinants of quality of life 6 months after transplantation: longitudinal prospective study.

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Psychiatric Approach to Liver Transplanted Patients' Unit, Curry Cabral Hospital's Liver Transplantation Center, Lisbon, Portugal.



We sought to investigate the psychosocial determinants of quality of life at 6 months after transplantation.


A sample of liver transplant candidates (n = 60), composed of consecutive patients (25% with familial amyloid polyneuropathy [FAP]) attending outpatient clinics was assessed in the pretransplant period using the Neo Five Factor Inventory, Hospital Anxiety and depression Scale (HADS), Brief COPE, and SF-36, a quality-of-life, self-rating questionnaire. Six months after transplantation, these patients were assessed by means of the SF-36.


Psychosocial predictors where found by means of multiple regression analysis. The physical component of quality of life at 6 months after transplantation was determined based upon coping strategies and physical quality of life in the pretransplant period (this model explained 32% of variance). The mental component at 6 months after transplantation was determined by depression in the pretransplant period and by clinical diagnoses of patients. Because FAP patients show a lower mental component of quality of life, this diagnosis explained 25% of the variance.


Our findings suggested that coping strategies and depression measured in the pretransplant period are important determinants of quality of life at 6 months after liver transplantation.

[Indexed for MEDLINE]

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