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Clin Oncol (R Coll Radiol). 2009 Aug;21(6):494-501. doi: 10.1016/j.clon.2009.02.008. Epub 2009 Apr 17.

Outcome of T1N0M0 squamous cell carcinoma of the larynx treated with short-course radiotherapy to a total dose of 50 Gy in 16 fractions: the Birmingham experience.

Author information

1
Cancer Centre, Queen Elizabeth Hospital, Birmingham B15 2TH, UK. nelliecheah@yahoo.co.uk

Abstract

AIMS:

To review the results of hypofractionated radiotherapy in T1N0M0 squamous cell carcinoma of the larynx.

MATERIALS AND METHODS:

A series of 100 patients treated with radiotherapy between 1993 and 2001 was reviewed. The median age was 67 years. The median follow-up was 7 years (range 3-14 years). Radiotherapy was delivered to a total dose of 50 Gy in 16 fractions treating daily, 5 days a week over 21 days.

RESULTS:

Locoregional control rates with radiotherapy alone were 92% at 2 years and 88% at 5 years. After salvage surgery, the ultimate locoregional control rate was 96%. The relapse-free survival rates at 2 and 5 years were 85 and 70%, respectively. The cause-specific survival rates at 2 and 5 years were 99 and 97%, respectively. Overall survival rates at 2 and 5 years were 91 and 76%, respectively. Second primary cancers occurred in 21% of patients, primarily in the lung.

CONCLUSIONS:

Radiotherapy to a total dose of 50 Gy in 16 fractions for T1N0M0 squamous cell carcinoma of the larynx offers high locoregional control rates with voice preservation. These results from a hypofractionated radiotherapy schedule are comparable with other longer fractionation schedules and offer potential for optimising resource usage.

PMID:
19375900
DOI:
10.1016/j.clon.2009.02.008
[Indexed for MEDLINE]

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