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J Pharm Biomed Anal. 2010 Jan 20;51(2):399-404. doi: 10.1016/j.jpba.2009.03.018. Epub 2009 Mar 25.

Metabolic profile of the bioactive compounds of burdock (Arctium lappa) seeds, roots and leaves.

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Department of Food Science, Via Università 100, University of Naples "Federico II", Parco Gussone Ed.84, 80055 Portici, Naples, Italy.


In this work the bioactive metabolic profile, the antioxidant activity and total phenolic content of burdock (Arctium lappa) seeds, leaves and roots were obtained. TEAC values and total phenolic content for hydro-alcoholic extracts of burdock ranged from 67.39 to 1.63 micromol Trolox equivalent/100g dry weight (DW), and from 2.87 to 45 g of gallic acid equivalent/100g DW, respectively. Phytochemical compounds were analyzed by liquid chromatography coupled to electrospray tandem mass spectrometry (LC/MS/MS) in negative mode. The main compounds of burdock extracts were caffeoylquinic acid derivatives, lignans (mainly arctiin) and various flavonoids. The occurrence of some phenolic acids (caffeic acid, chlorogenic acid and cynarin) in burdock seeds; arctiin, luteolin and quercetin rhamnoside in burdock roots; phenolic acids, quercetin, quercitrin and luteolin in burdock leaves was reported for the first time.

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