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Pharmacogenomics. 2009 Apr;10(4):601-21. doi: 10.2217/pgs.09.11.

Immunogenetics of drug-induced skin blistering disorders. Part I: Perspective.

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School of Biological Sciences, The University of Reading, Whiteknights, Reading, RG6 6AH, UK.


The overall immunopathogenesis relevant to a large series of disorders caused by a drug or its associated hyperimmune condition is discussed based upon the examination of the genetics of severe drug-induced bullous skin problems (sporadic idiosyncratic adverse events, including Stevens-Johnson syndrome and toxic epidermal necrolysis). An overarching pharmacogenetic schema is proposed. Immune cognition and early-effector processes are focused upon and a challenging synthesis around systems evolution is explained by a variety of projective analogies. Etiology, human leukocyte antigen-B, immune stability, dysregulation, pharmacomimicry, viruses and an aggressive ethnically differentiated 'karmic' response are discussed.

[Indexed for MEDLINE]

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