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J Nucl Med. 2009 May;50(5):667-70. doi: 10.2967/jnumed.108.058479. Epub 2009 Apr 16.

Recent advances in small-animal cardiovascular imaging.

Author information

1
Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. tsui@jhmi.edu

Abstract

Because of the development of gene knockout and transgenic technologies, small animals, such as mice and rats, have become the most widely used animals for cardiovascular imaging studies. Imaging can provide a method to serially evaluate the effect of a particular genetic mutation or pharmacologic therapy (1). In addition, imaging can be used as a noninvasive screening tool for particular cardiovascular phenotypes. Outcome measures of therapeutic efficacy, such as ejection fraction, left ventricular mass, and ventricular volume, can be determined noninvasively as well. Furthermore, small-animal imaging can be used to develop and test new molecular imaging probes (2,3). However, the small size of the heart and rapid heart rate of murine models create special challenges for cardiovascular imaging.

PMID:
19372476
PMCID:
PMC2866288
DOI:
10.2967/jnumed.108.058479
[Indexed for MEDLINE]
Free PMC Article

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