Format

Send to

Choose Destination
See comment in PubMed Commons below
Dev Biol. 2009 Jun 15;330(2):213-20. doi: 10.1016/j.ydbio.2009.04.011. Epub 2009 Apr 14.

Shaping the zebrafish heart: from left-right axis specification to epithelial tissue morphogenesis.

Author information

1
Hubrecht Institute and University Medical Centre Utrecht, 3584 CT, Utrecht, The Netherlands. j.bakkers@niob.knaw.nl

Abstract

Although vertebrates appear bilaterally symmetric on the outside, various internal organs, including the heart, are asymmetric with respect to their position and/or their orientation based on the left/right (L/R) axis. The L/R axis is determined during embryo development. Determination of the L/R axis is fundamentally different from the determination of the anterior-posterior or the dorsal-ventral axis. In all vertebrates a ciliated organ has been described that induces a left-sided gene expression program, which includes Nodal expression in the left lateral plate mesoderm. To have a better understanding of organ laterality it is important to understand how L/R patterning induces cellular responses during organogenesis. In this review, we discuss the current understanding of the mechanisms of L/R patterning during zebrafish development and focus on how this affects cardiac morphogenesis. Several recent studies have provided unprecedented insights into the intimate link between L/R signaling and the cellular responses that drive morphogenesis of this organ.

PMID:
19371733
DOI:
10.1016/j.ydbio.2009.04.011
[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center