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Br J Clin Pharmacol. 2009 Apr;67(4):455-9. doi: 10.1111/j.1365-2125.2009.03366.x.

Transfer of methylamphetamine and amphetamine into breast milk following recreational use of methylamphetamine.

Author information

1
School of Nursing and Midwifery, Faculty of Health Sciences, Curtin University of Technology, GPO Box U1987, Perth, Western Australia, 6845, Australia. anne.bartu@health.wa.gov.au

Abstract

AIMS:

To investigate the transfer of amphetamines into breast milk following their recreational use and estimate drug exposure for the breastfed infant.

METHODS:

Two breastfeeding mothers who were occasional recreational users of intravenous amphetamines were studied. A urine sample was collected 4 h after dose, and milk samples were collected over 24 h. Drug in urine was qualitatively identified by gas chromatography-mass spectrometry and quantification in milk was by high-performance liquid chromatography. Absolute infant dose via milk was estimated.

RESULTS:

The urines contained predominantly methylamphetamine together with smaller amounts of amphetamine. In the 24 h after dose, average concentrations in milk were 111 microg l(-1) and 281 microg l(-1) for methylamphetamine and 4 microg l(-1) and 15 microg l(-1) for amphetamine in cases 1 and 2, respectively. Absolute infant doses for methylamphetamine plus amphetamine (as methylamphetamine equivalents) were 17.5 microg kg(-1) day(-1) and 44.7 microg kg(-1) day(-1), respectively, for cases 1 and 2.

CONCLUSION:

These limited data suggest that breastfeeding should be withheld for 48 h after recreational amphetamine use.

PMID:
19371319
PMCID:
PMC2679109
DOI:
10.1111/j.1365-2125.2009.03366.x
[Indexed for MEDLINE]
Free PMC Article

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