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Clin Neuropsychol. 2009 Aug;23(6):944-61. doi: 10.1080/13854040802681664.

Leukoaraiosis severity and list-learning in dementia.

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1
Department of Clinical and Health Psychology, University of Florida, PO Box 100165, Gainesville, Florida, 32610, USA. cep23@phhp.ufl.edu

Abstract

In patients with dementia, leukoaraiosis (LA) was hypothesized to result in differential patterns of impairment on a verbal serial list-learning test. Using a visual rating scale, 144 dementia patients with ischemic scores <4 were re-categorized as having mild (n = 73), moderate (n = 44), or severe LA (n = 27). Mild LA was predicted to be associated with an amnestic list-learning profile, while severe LA was predicted to be associated with a dysexecutive profile. List-learning performances were standardized to a group of healthy older adults (n = 24). Analyses were conducted on a set of four factors derived from the list-learning paradigm, as well as error scores. Data indicate that LA severity is an important marker for understanding list learning in dementia.

PMID:
19370451
PMCID:
PMC2866111
DOI:
10.1080/13854040802681664
[Indexed for MEDLINE]
Free PMC Article
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