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Cell Mol Life Sci. 2009 Jul;66(14):2319-28. doi: 10.1007/s00018-009-0022-6. Epub 2009 Apr 16.

Cytoskeleton-membrane interactions in membrane raft structure.

Author information

1
Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA.

Abstract

Cell membranes are structurally heterogeneous, composed of discrete domains with unique physical and biological properties. Membrane domains can form through a number of mechanisms involving lipid-lipid and protein-lipid interactions. One type of membrane domain is the cholesterol-dependent membrane raft. How rafts form remains a current topic in membrane biology. We review here evidence of structuring of rafts by the cortical actin cytoskeleton. This includes evidence that the actin cytoskeleton associates with rafts, and that many of the structural and functional properties of rafts require an intact actin cytoskeleton. We discuss the mechanisms of the actin-dependent raft organization, and the properties of the actin cytoskeleton in regulating raft-associated signaling events. We end with a discussion of membrane rafts and the actin cytoskeleton in T cell activation, which function synergistically to initiate the adaptive immune response.

PMID:
19370312
PMCID:
PMC2709161
DOI:
10.1007/s00018-009-0022-6
[Indexed for MEDLINE]
Free PMC Article

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