Format

Send to

Choose Destination
J Invest Dermatol. 2009 May;129(5):1066-70. doi: 10.1038/jid.2008.425.

Scarring alopecia and the PPAR-gamma connection.

Author information

1
Department of Dermatological Sciences, University of Manchester, Manchester, UK.

Abstract

The pathobiology of primary cicatricial ("scarring") alopecia (PCA) remains poorly understood and underinvestigated. In this issue, Karnik et al. identify a previously unsuspected player, peroxisome proliferator-activated receptor-gamma (PPARgamma), in the pathogenesis of the most frequent form of PCA, lichen planopilaris (LPP). The authors show that PPARgamma is required for maintenance of a functional epithelial stem cell compartment in murine hair follicles, that the targeted deletion of PPARgamma in the bulge/isthmus area of the hair follicle epithelium generates a skin pathology that resembles LPP, and that LPP patients show gene expression changes that indicate a defect in lipid metabolism and peroxisome biogenesis. This study invites the revisitation of many open questions in PCA pathobiology and the exploration of new avenues for future PCA management.

PMID:
19369934
DOI:
10.1038/jid.2008.425
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center