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Bioinformatics. 2009 Jun 15;25(12):1564-5. doi: 10.1093/bioinformatics/btp253. Epub 2009 Apr 15.

Fluctuation analysis CalculatOR: a web tool for the determination of mutation rate using Luria-Delbruck fluctuation analysis.

Author information

1
Department of Cancer Genetics, Roswell Park Cancer Institute, Elm & Carlton Streets, Buffalo, NY 14263, USA. brandon.hall@roswellpark.org

Abstract

SUMMARY:

The program Fluctuation AnaLysis CalculatOR (FALCOR) is a web tool designed for use with Luria-Delbrück fluctuation analysis to calculate the frequency and rate from various mutation assays in bacteria and yeast. Three calculation methods are available through this program: (i) Ma-Sandri-Sarkar Maximum Likelihood Estimator (MSS-MLE) method, (ii) Lea-Coulson method of the median (LC) and (iii) frequency.

AVAILABILITY:

The FALCOR rate calculator is currently accessible at http://www.mitochondria.org/protocols/FALCOR.html. This program is written as a Java Applet, requiring a web browser enabled with Sun MicroSystems' Java Virtual Machine.

PMID:
19369502
PMCID:
PMC2687991
DOI:
10.1093/bioinformatics/btp253
[Indexed for MEDLINE]
Free PMC Article

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