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Bioorg Med Chem Lett. 2009 May 15;19(10):2780-4. doi: 10.1016/j.bmcl.2009.03.110. Epub 2009 Mar 27.

Discovery of 4-azaindoles as novel inhibitors of c-Met kinase.

Author information

1
UCB Celltech, Slough, United Kingdom. john.porter@ucb.com

Abstract

A series of 4-azaindole inhibitors of c-Met kinase is described. The postulated binding mode was confirmed by an X-ray crystal structure and series optimisation was performed on the basis of this structure. Future directions for series development are discussed.

PMID:
19369077
DOI:
10.1016/j.bmcl.2009.03.110
[Indexed for MEDLINE]

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