Format

Send to

Choose Destination
Vaccine. 2009 Apr 21;27(18):2418-25. doi: 10.1016/j.vaccine.2009.01.136. Epub 2009 Mar 3.

Granzyme B: Correlates with protection and enhanced CTL response to influenza vaccination in older adults.

Author information

1
Center for Immunotherapy of Cancer and Infectious Diseases, Department of Immunology, University of Connecticut School of Medicine, Farmington, 06030, USA. jmcelhaney@uchc.edu

Abstract

This study compared serum antibody titers and granzyme B (GrzB) levels in virus-stimulated peripheral blood mononuclear cells following influenza vaccination. Twelve of 239 older adults who subsequently developed laboratory-diagnosed influenza illness (LDI) had significantly lower GrzB levels compared to subjects without LDI (p=0.004). Eight subjects with LDI in the previous year showed an enhanced GrzB response to vaccination (p=0.02). Serum antibody titers following vaccination did not distinguish those older adults who developed LDI from those who did not. These results suggest that GrzB levels could be combined with antibody titers to more effectively predict vaccine efficacy in older adults.

PMID:
19368783
PMCID:
PMC2800816
DOI:
10.1016/j.vaccine.2009.01.136
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center