The pharmacokinetics of single dose intramuscular amoxicillin trihydrate in tammar wallabies (Macropus eugenii)

J Zoo Wildl Med. 2009 Mar;40(1):113-6. doi: 10.1638/2008-0104.1.

Abstract

Five tammar wallabies (Macropus eugenii) were injected intramuscularly with 10 mg/kg amoxicillin trihydrate. Serial blood samples were collected through to 26 hr postinjection. Plasma amoxicillin concentrations were measured using high-performance liquid chromatography. Pharmacokinetic parameters were estimated using noncompartmental analysis. The terminal half-life (1.77 +/- 0.40 hr) was comparable to that previously reported in domestic small ruminants. Without intravenous kinetic data, it is unclear whether the terminal phase is elimination- or absorption-dependent; both scenarios have been reported in domestic species. Plasma concentrations of amoxicillin remained above a reported minimum inhibitory concentration (MIC) breakpoint for staphylococci and streptococci for at least 8 hr; the MIC breakpoint for enterobacteria and enterococci was never attained.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amoxicillin / blood
  • Amoxicillin / pharmacokinetics*
  • Animals
  • Anti-Bacterial Agents / blood
  • Anti-Bacterial Agents / pharmacokinetics*
  • Area Under Curve
  • Chromatography, High Pressure Liquid / methods
  • Chromatography, High Pressure Liquid / veterinary
  • Dose-Response Relationship, Drug
  • Female
  • Half-Life
  • Injections, Intramuscular / veterinary
  • Macropodidae / blood*
  • Microbial Sensitivity Tests / veterinary
  • Species Specificity

Substances

  • Anti-Bacterial Agents
  • Amoxicillin