Format

Send to

Choose Destination
Arch Ophthalmol. 2009 Apr;127(4):563-71. doi: 10.1001/archophthalmol.2009.65.

Stem cells as tools in regenerative therapy for retinal degeneration.

Author information

1
Department of Ophthalmology, Inselspital, University of Bern, Bern, Switzerland.

Abstract

OBJECTIVE:

To describe the use of stem cells (SCs) for regeneration of retinal degenerations. Regenerative medicine intends to provide therapies for severe injuries or chronic diseases where endogenous repair does not sufficiently restore the tissue. Pluripotent SCs, with their capacity to give rise to specialized cells, are the most promising candidates for clinical application. Despite encouraging results, a combination with up-to-date tissue engineering might be critical for ultimate success.

DESIGN:

The focus is on the use of SCs for regeneration of retinal degenerations. Cell populations include embryonic, neural, and bone marrow-derived SCs, and engineered grafts will also be described.

RESULTS:

Experimental approaches have successfully replaced damaged photoreceptors and retinal pigment epithelium using endogenous and exogenous SCs.

CONCLUSIONS:

Stem cells have the potential to significantly impact retinal regeneration. A combination with bioengineering may bear even greater promise. However, ethical and scientific issues have yet to be solved.

PMID:
19365041
PMCID:
PMC3192438
DOI:
10.1001/archophthalmol.2009.65
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Silverchair Information Systems Icon for PubMed Central
Loading ...
Support Center