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Bioorg Med Chem. 2009 May 1;17(9):3342-51. doi: 10.1016/j.bmc.2009.03.041. Epub 2009 Mar 26.

Identification and SAR of squarate inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2).

Author information

1
Chemical Sciences, Wyeth Research, Cambridge, MA 02140, USA. flovering@wyeth.com

Abstract

A novel series of inhibitors for mitogen activated protein kinase-activated protein kinase 2 (MK-2) are reported. These squarate based inhibitors were identified via a high-throughput screen. An MK2 co-structure with the starting ligand was obtained and a structure based approach was followed to optimize potency and selectivity.

PMID:
19364658
DOI:
10.1016/j.bmc.2009.03.041
[Indexed for MEDLINE]

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