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Biochem Biophys Res Commun. 2009 Jun 12;383(4):417-20. doi: 10.1016/j.bbrc.2009.04.022. Epub 2009 Apr 11.

Four spatial points that define enzyme families.

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1
Protein Information Technology Group, Eötvös University, 1117 Budapest, Hungary.

Abstract

The catalytic properties of enzymes, containing the Asp-His-Ser triads are deeply investigated for a long time. Serine endopeptidases, cutinases, acetylcholinesterases, cellulases, among other enzymes, contain these triads. We found that solely the geometric properties of just four points in the spatial structure of these enzymes are characteristic to their family.

PMID:
19364497
DOI:
10.1016/j.bbrc.2009.04.022
[Indexed for MEDLINE]
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