Format

Send to

Choose Destination
See comment in PubMed Commons below
Int J Artif Organs. 2009 Feb;32(2):95-100.

The control of hyperphosphatemia in chronic kidney disease: which phosphate binder?

Author information

1
Division of Nephrology, Coburg Clinic, Coburg - Germany. markus.ketteler@klinikum-coburg.de

Abstract

Hyperphosphatemia is currently regarded as a key mortality risk predictor in late CKD stages and especially in patients on dialysis. Fortunately, the armatorium to effectively treat hyperphosphatemia in end-stage renal disease has grown in recent years, and we gained an improved understanding of potential benefits and harms of specific compounds. Most interestingly, novel insights into the pathophysiology of calcium and phosphate handling, especially, the discovery of the phosphatonin FGF23, suggest a more complex assessment of phosphate balance especially in predialysis stages is warranted. This assessment should probably include measurements of fractional phosphate excretion and phosphatonin levels to objectively judge and effectively correct phosphate overload, however, clinical data on calcium and phosphate metabolism in CKD stages 3 - 4 are still scarce. This overview will both discuss aspects of pathophysiology of phosphate regulation and current and future clinical treatement approaches.

PMID:
19363781
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wichtig Publishing
    Loading ...
    Support Center