Format

Send to

Choose Destination
Bioorg Med Chem Lett. 2009 May 15;19(10):2835-9. doi: 10.1016/j.bmcl.2009.03.102. Epub 2009 Mar 26.

Identification and characterization of a selective radioligand for melanin-concentrating hormone 1-receptor (MCH1R).

Author information

1
Department of Metabolic Disorder, Tsukuba Research Institute, BANYU Pharmaceutical Co., Ltd, Okubo, Ibaraki, Japan. masahiko_ito2@merck.com

Abstract

We have developed and characterized [(35)S]4a as a potent and selective radioligand for melanin-concentrating hormone 1-receptor (MCH1R). Compound [(35)S]4a showed appreciable specific signals in brain slices prepared from wild-type mice but not from MCH1R deficient mice, confirming the specificity and utility of [(35)S]4a as a selective MCH1R radioligand for ex vivo receptor occupancy assays.

PMID:
19361985
DOI:
10.1016/j.bmcl.2009.03.102
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center