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Nat Rev Cancer. 2009 May;9(5):371-7. doi: 10.1038/nrc2604. Epub 2009 Apr 9.

The ups and downs of p53: understanding protein dynamics in single cells.

Author information

1
Harvard Medical School Systems Biology, Boston, MA 02115, USA.

Abstract

Cells living in a complex environment must constantly detect, process and appropriately respond to changing signals. Therefore, all cellular information processing is dynamic in nature. As a consequence, understanding the process of signal transduction often requires detailed quantitative analysis of dynamic behaviours. Here, we focus on the oscillatory dynamics of the tumour suppressor protein p53 as a model for studying protein dynamics in single cells to better understand its regulation and function.

PMID:
19360021
PMCID:
PMC2892289
DOI:
10.1038/nrc2604
[Indexed for MEDLINE]
Free PMC Article

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