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Trends Biochem Sci. 2009 May;34(5):230-3. doi: 10.1016/j.tibs.2008.12.009. Epub 2009 Apr 7.

Polypeptide transfer from Hsp40 to Hsp70 molecular chaperones.

Author information

1
Department of Cell and Developmental Biology, University of North Carolina at Chapel Hill, NC 27599-7090, USA.

Abstract

Heat shock protein 40 (Hsp40) co-chaperones assist in cellular protein folding and degradation through the binding and delivery of non-native proteins to heat shock protein 70 (Hsp70). The mechanism for substrate transfer from Hsp40s to Hsp70 is unknown. Two recent studies provide new details that shed light on novel mechanisms for substrate recognition by Hsp40s and a common mechanism for polypeptide transfer to Hsp70.

PMID:
19359181
PMCID:
PMC4437460
DOI:
10.1016/j.tibs.2008.12.009
[Indexed for MEDLINE]
Free PMC Article

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