Format

Send to

Choose Destination
Bioorg Med Chem Lett. 2009 May 15;19(10):2840-3. doi: 10.1016/j.bmcl.2009.03.101. Epub 2009 Mar 26.

Exploring bis-(indolyl)methane moiety as an alternative and innovative CAP group in the design of histone deacetylase (HDAC) inhibitors.

Author information

1
Sigma-Tau Research and Development, Pomezia, Roma, Italy. giuseppe.giannini@sigma-tau.it

Abstract

In order to gather further knowledge about the structural requirements on histone deacetylase inhibitors (HDACi), starting from the schematic model of the common pharmacophore that characterizes this class of molecules (surface recognition CAP group-connection unit-linker region-Zinc Binding Group), we designed and synthesized a series of hydroxamic acids containing a bis-(indolyl)methane moiety. HDAC inhibition profile and antiproliferative activity were evaluated.

PMID:
19359173
DOI:
10.1016/j.bmcl.2009.03.101
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center