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Fitoterapia. 2009 Jul;80(5):301-5. doi: 10.1016/j.fitote.2009.03.009. Epub 2009 Apr 7.

Pomegranate fruit components modulate human thrombin.

Author information

1
Department of Molecular, Cellular & Animal Biology, University of Camerino, Italy.

Abstract

Pomegranate (Punica granatum) is an important source of polyphenols with assessed antioxidant properties. The aims of this study were: (i) the characterization of the monomeric phenolic variability on each isolated fruit component (endocarp, mesocarp, aril); (ii) the study on the effect of pomegranate fruit components on human thrombin amidolytic activity. Collectively, our data show that pomegranate components contain bioactive metabolites (mainly ellagic acid) and suggest a potential role for the pomegranate extract in the regulation of a number of physio-pathological processes involving thrombin (or thrombin-like proteinase).

PMID:
19358882
DOI:
10.1016/j.fitote.2009.03.009
[Indexed for MEDLINE]

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