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Clin Nutr. 2009 Jun;28(3):249-55. doi: 10.1016/j.clnu.2009.03.005. Epub 2009 Apr 8.

Critically ill infants benefit from early administration of protein and energy-enriched formula: a randomized controlled trial.

Author information

1
Department of Pediatrics, Maastricht University and Medical Center, P Debeyelaan 25, Maastricht, The Netherlands. d.vanwaardenburg@mumc.n

Abstract

BACKGROUND & AIMS:

Nutritional support improves outcome in critically ill infants but is impeded by fluid restriction, gastric intolerance and feeding interruptions. Protein and energy-enriched infant formulas may help to achieve nutritional targets earlier during admission and promote anabolism.

METHODS:

Randomized controlled design. Infants with respiratory failure due to RSV-bronchiolitis received a protein and energy-enriched formula (PE-formula, n=8) or a standard formula (S-formula, n=10) during 5 days after admission.

PRIMARY OUTCOME:

nutrient delivery, energy and nitrogen balance and plasma amino acid concentrations. Secondary outcome: tolerance and safety.

RESULTS:

Nutrient intakes were higher in PE fed infants and met population reference intake (PRI) on day 3-5 whilst in S-fed infants PRI was met on day 5 only. Cumulative nitrogen balance (cNB) and energy balance (cEB) were higher in PE-infants compared to S-infants (cNB: 866+/-113 vs. 296+/-71 mg/kg; cEB: 151+/-31 and 26+/-17 kcal/kg, both P<0.01). Essential amino acid levels were higher in PE-infants but within reference limits whereas below these limits in S-infants. Both formulas were well tolerated.

CONCLUSIONS:

Early administration of a protein and energy-enriched formula in critically ill infants is well tolerated, promotes a more adequate nutrient intake and improves energy and nitrogen balance without adverse effects.

PMID:
19356829
DOI:
10.1016/j.clnu.2009.03.005
[Indexed for MEDLINE]

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