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Cell Metab. 2009 Apr;9(4):303-5. doi: 10.1016/j.cmet.2009.03.008.

The insulin receptor talks to glucagon?

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1
Novartis Institutes for BioMedical Research, 100 Technology Square, Cambridge, MA 02139, USA. jesper.gromada@novartis.com

Abstract

Type 2 diabetes (T2DM) is not only a disorder of impaired insulin secretion but also glucagon oversecretion. However, the link between the two remains unclear. Is it possible that the latter is a consequence of the former? In this issue, Kawamori et al. (2009) have addressed this question by generating alpha cell-specific insulin receptor knockout mice.

PMID:
19356709
DOI:
10.1016/j.cmet.2009.03.008
[Indexed for MEDLINE]
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