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J Org Chem. 2009 Apr 17;74(8):3148-51. doi: 10.1021/jo8027533.

Brønsted acid-catalyzed propargylation/cycloisomerization tandem reaction: one-pot synthesis of substituted oxazoles from propargylic alcohols and amides.

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1
Department of Chemistry, College of Chemistry and Chemical Engineering, and State Key Laboratory for Physical Chemistry of Solid Surfaces, Xiamen University, Xiamen 361005, People's Republic of China.

Abstract

An efficient one-pot propargylation/cycloisomerization tandem process has been developed for the synthesis of substituted oxazole derivatives from propargylic alcohols and amides with use of p-toluenesulfonic acid monohydrate (PTSA) as a bifunctional catalyst. This method provides a rapid and efficient access to substituted oxazoles.

PMID:
19354325
DOI:
10.1021/jo8027533
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