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J Zhejiang Univ Sci B. 2009 Apr;10(4):258-63. doi: 10.1631/jzus.B0820261.

Prebiotic oligosaccharides change the concentrations of short-chain fatty acids and the microbial population of mouse bowel.

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1
Department of Chemistry, Zhejiang University, Hangzhou 310027, China.

Abstract

The purpose of this study was to clarify effects of selected oligosaccharides on concentrations of cecal short-chain fatty acids (SCFAs), total large bowel wet weight and wall weight, and cecal microbiota levels in mice. Mice were respectively given gavage of selected fructooligosaccharides (FOS), galactooligosaccharides (GOS), mannanoligosaccharides (MOS), and chitooligosaccharides (COS) [1000 mg/(kg body weight.d)]. Control group was given physiological saline solution. After 14 d treatment, SCFAs and lactate in mice cecum were significantly increased (P<0.05) by intake of oligosaccharides, especially FOS and GOS. Thus, providing these oligosaccharides as ingredients in nutritional formulas may benefit the gastrointestinal tract.

PMID:
19353743
PMCID:
PMC2666202
DOI:
10.1631/jzus.B0820261
[Indexed for MEDLINE]
Free PMC Article

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