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Chem Biodivers. 2009 Apr;6(4):561-8. doi: 10.1002/cbdv.200800163.

Non-nucleoside HIV-1 reverse transcriptase inhibitors. Part 13: synthesis of fluorine-containing diaryltriazine derivatives for in vitro anti-HIV evaluation against wild-type strain.

Author information

1
School of Pharmacy, Fudan University, Shanghai 200031, P. R. China.

Abstract

A series of diaryltriazine derivatives modified at C(2) of the triazine ring with a fluorinated phenyl group has been synthesized and tested for the ability to inhibit HIV-1 replication. Most of these F-containing compounds showed low-to-moderate anti-HIV activity in MT-4 cells.

PMID:
19353537
DOI:
10.1002/cbdv.200800163
[Indexed for MEDLINE]

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