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Curr Opin Obstet Gynecol. 2009 Jun;21(3):253-9. doi: 10.1097/GCO.0b013e32832a17a5.

The use of coculture in assisted reproductive technology: does it have any impact?

Author information

1
Department of Obstetrics and Gynecology, Division of Reproductive Medicine and Infertility, Baskent University, Kubilay Sok 36, Maltepe 06570, Ankara, Turkey. hulusi.zeyneloglu@gmail.com

Abstract

PURPOSE OF REVIEW:

To evaluate the current place of cocultures in in-vitro fertilization. The cocultures may have a role in a very special group of patients who had incompetent embryos grown in the conventional media.

RECENT FINDINGS:

There is evidence that cocultures help embryos to grow better; however, there is not enough evidence that these are better than the modern sequential media. After U.S. Food and Drug Administration restricted the use of cocultures to only autologous ones, granulosa cell cocultures may help some germinal vesicular oocytes to be rescued to meiosis II oocytes and may increase blastocyst formation rate to increase the pregnancy rate.

SUMMARY:

Autologous cocultures may help embryos to grow better; however, better-designed studies are needed to evaluate their effect.

PMID:
19352179
DOI:
10.1097/GCO.0b013e32832a17a5
[Indexed for MEDLINE]

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