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J Am Chem Soc. 2009 Apr 29;131(16):5728-9. doi: 10.1021/ja900591t.

Photoregulated release of caged anticancer drugs from gold nanoparticles.

Author information

1
Department of Chemistry, University of Massachusetts, 710 North Pleasant Street, Amherst, Massachusetts 01003, USA.

Abstract

An anticancer drug (5-fluorouracil) was conjugated to the surface of gold nanoparticles through a photocleavable o-nitrobenzyl linkage. In this system, the particle serves as both cage and carrier for the therapeutic, providing a nontoxic conjugate that effectively releases the payload upon long wavelength UV irradiation.

PMID:
19351115
PMCID:
PMC2673701
DOI:
10.1021/ja900591t
[Indexed for MEDLINE]
Free PMC Article

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