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Nat Immunol. 2009 May;10(5):488-95. doi: 10.1038/ni.1724. Epub 2009 Apr 6.

Cross-presentation of viral and self antigens by skin-derived CD103+ dendritic cells.

Author information

1
The Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria, Australia.

Abstract

Skin-derived dendritic cells (DCs) include Langerhans cells, classical dermal DCs and a langerin-positive CD103(+) dermal subset. We examined their involvement in the presentation of skin-associated viral and self antigens. Only the CD103(+) subset efficiently presented antigens of herpes simplex virus type 1 to naive CD8(+) T cells, although all subsets presented these antigens to CD4(+) T cells. This showed that CD103(+) DCs were the migratory subset most efficient at processing viral antigens into the major histocompatibility complex class I pathway, potentially through cross-presentation. This was supported by data showing only CD103(+) DCs efficiently cross-presented skin-derived self antigens. This indicates CD103(+) DCs are the main migratory subtype able to cross-present viral and self antigens, which identifies another level of specialization for skin DCs.

PMID:
19349986
DOI:
10.1038/ni.1724
[Indexed for MEDLINE]

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