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J Wound Care. 2009 Apr;18(4):164-7.

Effect of TNP on the microbiology of venous leg ulcers: a pilot study.

Author information

1
Christchurch School of Medicine, University of Otago, New Zealand. manar.khashram@gmail.com

Abstract

OBJECTIVE:

To investigate the effect of topical negative pressure, delivered using Vacuum Assisted Closure (VAC, KCI), on the microbiology of chronic, non-infected venous leg ulcers (VLUs).

METHOD:

Patients receiving compression therapy for a chronic VLU were recruited into this prospective pilot study. The ulcer was swabbed and VAC was applied at 125mmHg continuous sub-atmospheric pressure on day 1 for six days. Standard methods for bacteriological sampling and measuring the wound surface area were applied at baseline and at the VAC dressing changes on days 3 and 6. Log median colony forming units (CFUs) per cm2 were used for statistical analyses. The bacterial species were identified.

RESULTS:

Seven patients were recruited into and completed the study. The median log10 CFU/cm2 on days 1, 3 and 6 were 3.5, 4.7 and 5.1 respectively. There was a significant increase in bacterial colonisation between days 1 and 6 (p<0.02). No change was observed in the identified microbiological species during therapy with VAC.

CONCLUSION:

This pilot study suggests that VAC therapy increases absolute numbers of bacteria colonising non-infected leg ulcers.

DECLARATION OF INTEREST:

KCI supplied the VAC equipment and ARANZ the SilhouetteMobile, but both had no other influence on the study.

PMID:
19349936
DOI:
10.12968/jowc.2009.18.4.41608
[Indexed for MEDLINE]

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