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Neuroreport. 2009 May 6;20(7):657-62. doi: 10.1097/WNR.0b013e328329a449.

Propofol induces ERK-dependant expression of c-Fos and Egr-1 in neuronal cells.

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1
Department of Anesthesiology, New York Methodist Hospital, Brooklyn, New York, USA.

Abstract

This study explored the effects of propofol on c-Fos and Egr-1 in neuroblastoma (N2A) cells. We demonstrate that propofol induced the expression of c-Fos and Egr-1 within 30 and 60 min of exposure time. At 16.8 microM concentration, propofol induced a 6 and 2.5-fold expression of c-Fos and Egr-1, respectively. However, at concentrations above 100 microM, propofol failed to induce expression of c-Fos or Egr-1. Propofol-induced c-Fos and Egr-1 transcription was unaffected by bicuculline, a gamma-aminobutyric acid-A receptor antagonist, but was abolished by PD98059, a mitogen-activated protein kinase/extracellular signal-regulated kinase inhibitor. Our study shows that clinically relevant concentrations of propofol induce c-Fos and Egr-1 expression through an extracellular signal-regulated kinase mediated and gamma-aminobutyric acid-A independent pathway.

PMID:
19349923
PMCID:
PMC2801809
DOI:
10.1097/WNR.0b013e328329a449
[Indexed for MEDLINE]
Free PMC Article

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