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Bioorg Med Chem Lett. 2009 May 1;19(9):2504-8. doi: 10.1016/j.bmcl.2009.03.034. Epub 2009 Mar 14.

4-Phenyl-7-azaindoles as potent and selective IKK2 inhibitors.

Author information

1
GlaxoSmithKline R&D, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, UK.

Abstract

The synthesis and SAR of a novel series of IKK2 inhibitors are described. Modification around the hinge binding region of the 7-azaindole led to a series of potent and selective inhibitors with good cellular activity.

PMID:
19349179
DOI:
10.1016/j.bmcl.2009.03.034
[Indexed for MEDLINE]

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