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Gastroenterol Clin Biol. 2009 Jun-Jul;33(6-7):478-84. doi: 10.1016/j.gcb.2008.09.021. Epub 2009 Apr 5.

Efficacy of an activated charcoal-simethicone combination in dyspeptic syndrome: results of a randomized prospective study in general practice.

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1
Service de Médecine Générale, Lognes, France.

Abstract

AIM:

The aim of this prospective, multicenter, randomized, placebo-controlled trial was to evaluate the efficacy of a commercial combination of simethicone and activated charcoal (Carbosylane) on dyspeptic symptoms in patients consulting a general practitioner.

PATIENTS AND METHODS:

A total of 132 patients were studied. Treatment duration was 3 months, followed by a 2 months follow-up period.

RESULTS:

At the end of the treatment period, the percentage of patients with a reduction of at least two points on the symptom intensity scale was significantly higher with Carbosylane than with a placebo (P=0.043). Compared with placebo, the intensity of three symptoms (abdominal fullness, bloating and the sensation of slow digestion) was significantly decreased after 90 days of Carbosylane (P<0.05). At the end of the post-treatment follow-up, the percentages of patients with moderate or severe global complaints were 6.78% and 21.43% in the Carbosylane and placebo groups, respectively (P<0.03).

CONCLUSION:

Among patients consulting a general practitioner for dyspeptic syndrome, 3 months of treatment with Carbosylane resulted in significant symptomatic improvement. The improvement was still evident 2 months after the end of treatment.

PMID:
19349130
DOI:
10.1016/j.gcb.2008.09.021
[Indexed for MEDLINE]
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