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Microbes Infect. 2009 May-Jun;11(6-7):716-20. doi: 10.1016/j.micinf.2009.03.008. Epub 2009 Apr 5.

Experimental infection of cats with Bartonella henselae resulted in rapid clearance associated with T helper 1 immune responses.

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Laboratory of Veterinary Public Health, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Fujisawa, Kanagawa, Japan.


Six cats were inoculated with Bartonella henselae strains A and B, which were isolated from the same naturally infected cat. The numbers of CD4(+) cells decreased following the infection. The levels of bacteremia were significantly correlated with the expression levels of IFN-gamma mRNA during the various stages of bacteremia and elimination of the bacteremia. Furthermore, the lower levels of TNF-alpha mRNA expression during the bacteremia related to the emergence of higher levels of bacteremia. These results indicate that the activation of cell-mediated immune responses, including IFN-gamma and TNF-alpha production, play an important role in elimination of B. henselae from bacteremic cats.

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