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Microbes Infect. 2009 May-Jun;11(6-7):637-45. doi: 10.1016/j.micinf.2009.03.009. Epub 2009 Apr 5.

Porphyromonas gingivalis-host interactions: open war or intelligent guerilla tactics?

Author information

1
Department of Periodontics/Oral Health and Systemic Disease, School of Dentistry, University of Louisville Health Sciences Center, Louisville, KY 40292, USA. g0haji01@louisville.edu

Abstract

This review summarizes and discusses virulence mechanisms whereby Porphyromonas gingivalis can persist in the oral cavity. It is proposed that the virulence of P. gingivalis is dependent, at least in part, upon its ability to establish a complex host-pathogen molecular crosstalk which subverts innate immunity. The sophisticated stealth and sabotage tactics used by P. gingivalis may additionally benefit co-habiting organisms occupying the same niche.

PMID:
19348960
PMCID:
PMC2704251
DOI:
10.1016/j.micinf.2009.03.009
[Indexed for MEDLINE]
Free PMC Article

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