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J Clin Invest. 2009 Apr;119(4):760-3.

Can licorice lick colon cancer?

Author information

1
College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom. p.m.stewart@bham.ac.uk

Abstract

COX-2 promotes colon cancer. While both nonselective NSAIDs and selective COX-2 inhibitors reduce disease burden, their adverse gastrointestinal and cardiovascular side effects limit their therapeutic use. In this issue of the JCI, Zhang et al. used gene silencing and a derivative of licorice root to show that inhibition of the enzyme 11beta-hydroxysteroid dehydrogenase type II(11betaHSD2) reduces tumor COX-2 activity, tumor growth, and metastasis by increasing the tonic glucocorticoid-mediated suppression of the COX-2 signaling pathway without the adverse effects associated with NSAIDs and selective COX-2 inhibitors (see the related article beginning on page 876). Their findings suggest that 11betaHSD2 inhibition may be a potential therapeutic option in colon cancer, warranting further investigation.

PMID:
19348044
PMCID:
PMC2662579
DOI:
10.1172/jci38936
[Indexed for MEDLINE]
Free PMC Article

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